Cohort Description

Radboud University Medical Centre: Nijmegen 1985 Inception Cohort

The Nijmegen inception cohort was initiated at the department of rheumatology in the Radboud University Medical Centre in 1985. Patients are included at diagnosis of rheumatoid arthritis (RA) in the out-patient clinic of the departments of rheumatology of the Radboud UMC (since 1985) or the Maartenskliniek in Nijmegen (since 1990).

At inclusion, patients have a disease duration of less than 12 months and are disease modifying anti-rheumatic drug naive and fulfill the 1987 ACR (inclusion before 2010) or ACR/EULAR 2010 criteria (inclusion after 2010). After inclusion, patients are followed throughout the rest of the course of RA until death. Enrolled patients are seen every 3-6 months. During these visits, elaborate data on demographics, biomarkers, disease activity, (co-)medication and comorbidity is collected. More than 1200 patients are included in the total cohort today.

Data on cardiovascular (CV) events and CV risk factors were collected through extensive chart and electronic patient record review. Deaths due to CV disease were verified from death certificates, provided by Statistics Netherlands. A total of 1157 RA patients from the Nijmegen inception cohort were contributed to the total ATACC-RA cohort, with 266 CV events of which 181 are first events.