Radboud University Medical Centre, Netherlands

Research group Rheumatology department Radboud University Medical Centre.

The rheumatology department is equipped with an excellent infrastructure for performing clinical and experimental research into rheumatic disorders.

The laboratory for experimental rheumatology, embedded in the NCMLS, has a world-wide renowned reputation. Our research is directed at the identification of new targets for cartilage destruction in rheumatoid arthritis and osteoarthritis, understanding the mechanisms of chronic inflammation and auto-immunity, and the development of advanced therapeutics.

The clinical research group has a strong reputation because of the research into the assessment and prognosis of rheumatoid arthritis and systemic sclerosis. The Disease Activity Score was developed here, and is used world-wide for the assessment of inflammatory activity in rheumatoid arthritis. Our research is directed at refinement of prognostic predictions, ‘tight control’ strategies for tailored treatment algorithms in rheumatoid arthritis, and understanding patient and physician decision making processes. Major patient consequences of RA are fatigue and cardiovascular disease, in both we perform research aimed at personalized treatment. Prediction of cardiovascular risk and appropriate treatment of cardiovascular risk currently are the main topics of research regarding rheumatoid arthritis and cardiovascular disease.