Brigham & Women’s hospital, US

Brigham Rheumatoid Arthritis Sequential Study (BRASS)

The purpose of BRASS, under the direction of Drs. Nancy Shadick and Michael Weinblatt, is to determine how genes can be used to predict whether rheumatoid arthritis (RA) will be mild or severe and to better understand how individuals respond to different drug treatments. BRASS is a longitudinal cohort study of ~1300 individuals diagnosed with RA who are patients at Brigham and Women’s Hospital Arthritis Center. Patients are followed in the clinic annually and sent questionnaires at six month intervals to assess metrics such as disease activity, functional status and quality of life. Since it’s inception in 2003, BRASS now has over a decade of rich clinical data on its participants.